Search results for "centrālā nervu sistēma"

showing 2 items of 2 documents

Peptīdu lunasīna un RGD regulējošā darbība peļu šizofrēnijas modeļos

2018

Lunasīns ir bioloģiski aktīvs peptīds, kam piemīt antioksidatīvas, pretiekaisuma, pretvēža un holesterīna biosintēzi regulējošas īpašības. Nesen atklāts, ka tas spēj ietekmēt arī centrālo nervu sistēmu, izmainot peļu uzvedību, tādējādi radās interese pētīt lunasīna un tā sastāvā esošā tripeptīda RGD centrālos efektus. Maģistra darba mērķis bija pētīt intranazāli ievadītu peptīdu lunasīna un RGD darbību peļu šizofrēnijas modeļos, izmantojot atvērtā lauka testu un nosakot VMAT2 ekspresiju ar Western blot metodi. Iegūtie rezultāti rāda, ka gan lunasīns, gan RGD samazina amfetamīna un DOI izraisīto peļu horizontālo lokomotoro hiperaktivitāti, bet neietekmē fenciklidīna izraisīto vispārējo horiz…

RGDlokomotorā aktivitāteFarmācijaLunasīnscentrālā nervu sistēma

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Centrālās nervu sistēmas ietekme uz adenohipofīzes adenomu attīstību

2015

Adenohipofīzes adenomas ir labdabīgi intrakraniāli endokrīnie audzēji ar potenciāli augstu prevalenci populācijā. To rašanās rezultātā pacientiem var attīstīties plaša spektra veselības problēmas. Bakalaura darbā veikta adenohipofīzes adenomu šūnu izpēte, analizējot to proliferāciju un saistību ar CNS. Darba gaitā tika konstatētas dažādas CNS cilmes šūnām raksturīgās īpašības adenomu paraugos.

cilmes šūnasadenohipofīzes adenomasBioloģijacentrālā nervu sistēmaimunohistoķīmija

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PEPhysical Sciences and Engineering
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